Nestled between rolling hills topped with colorful houses and meandering coastal dunes, the bustling city of San Antonio enjoys its reputation as the gateway to Chile’s central valley and the capital of Santiago. With a population of over five million people, Santiago sprawls at the feet of the snow-capped Andes. Inland lies the sun-kissed wine regions of Casablanca and Maipo Maipo Valley, Chile’s internationally renowned wine district.

Coquimbo is a port city, commune and capital of the Elqui Province, located on the Pan-American Highway, in the Coquimbo Region of Chile. Coquimbo is situated in a valley 10 km south of La Serena, with which it forms Greater La Serena with more than 400,000 inhabitants.

San Martin is your gateway to the quiet colonial town of Pisco and its fertile coastal valley. For thousands of years, pre-Columbian societies thrived in river valleys such as this. Utilizing sophisticated systems of irrigation, they transformed the harsh coastal desert into productive farmland. The legacy of these ancient people, from their giant geometric etchings on the desert floor to their ancient burial grounds, continues to draw curious adventurers from around the world. San Martin is also your gateway to two other mysterious marvels: the Inca palace complex at Machu Picchu and the Galapagos Archipelago.

In 1535, Francisco Pizarro labeled the open plains where Lima now stands as inhospitable. Despite the verdict of the great conquistador, Lima became the center of imperial Spanish power, a “City of Kings” where 40 viceroys would rule as the direct representatives of the King of Spain. With independence in 1821, Lima became Peru’s capital. Near Lima, one of the world’s most desolate deserts is home to the famed drawings of Nazca. These drawings inspired Erik von Daniken’s best-selling book “Chariots of the Gods.” With mysteries seeming to be part of Peru’s history, perhaps these “drawings” are in fact “the largest astronomy book in the world.”

In 1535, Francisco Pizarro labeled the open plains where Lima now stands as inhospitable. Despite the verdict of the great conquistador, Lima became the center of imperial Spanish power, a “City of Kings” where 40 viceroys would rule as the direct representatives of the King of Spain. With independence in 1821, Lima became Peru’s capital. Near Lima, one of the world’s most desolate deserts is home to the famed drawings of Nazca. These drawings inspired Erik von Daniken’s best-selling book “Chariots of the Gods.” With mysteries seeming to be part of Peru’s history, perhaps these “drawings” are in fact “the largest astronomy book in the world.”

The breezy, seaside city of Manta is the second largest port in Ecuador and possesses one of the world’s most varied terrains. To the west of Manta lie the Galapagos Islands. To the east rises the great rampart of the Andes. The Mantas were known for their traditional balsa rafts in the coastal waters and their ceramics and pottery. A huge tuna statue greets you on its shores, a whimsical nod to the tuna capital of the world. Fresh seafood is always on the menu, and a stroll along the promenade lets you take in the beach scene. The bustling center of town, an easy walk from port, displays a lively marketplace selling Panama hats, silver jewelry and apparel. There is lush green parkland; the nearby colonial town of Montecristi, the center of the Panama hat industry; and the Pacoche Wildlife Refuge, home to indigenous flora and fauna and cheeky howler monkeys. Explore the rich culture, heritage and people of Manta during scenic adventures that take in the Archaeological Museum, which highlights a small, well-curated collection of ceramics of the Manteño-Huancavilca culture that flourished here between 800 and 1550 A.D. Whether you explore its past or its vibrant city of today, a day in Manta is a rich and colorful experience.

Note: Manta offers little in the way of tourist infrastructure. Transportation and tour guides are imported to the area. Despite the sometimes hot and humid conditions there is no guarantee of air-conditioned vehicles.

To Spanish explorers, the rumors of gold and vast riches could only mean that this section of Central America was the costa rica – the “Rich Coast.”

Hailed as the Switzerland of the Americas, Costa Rica occupies a unique position, lying between two oceans and two continents. On both coasts, tropical rainforests rise to the mountains of the interior, many of which soar over 13,000 feet above sea level. In the west, a seemingly endless succession of brown-sand beaches forms the nation’s Pacific coast. Puntarenas is your gateway to Costa Rica’s wonders – and to its capital city of San Jose.

Puerto Vallarta is a resort town on Mexico’s Pacific coast, in Jalisco state. It is known for its beaches, water sports and nightlife scene. Its cobblestone center is home to the ornate Nuestra Señora de Guadalupe church, boutique shops and a range of restaurants and bars.

Millennia ago, Cabo San Lucas was part of the Mexican mainland. Then a massive rupture of the San Andreas Fault sent the waters of the Pacific crashing into the newly formed depression, creating the Sea of Cortez and the Baja Peninsula. Lying at the very tip of Baja, where the Pacific meets the Sea of Cortez, Cabo San Lucas – or “Cabo” – is one of the premier resort destinations in the Western Hemisphere. Swim in the transparent waters, marvel at the wealth of marine life, relax on one of the white-sand beaches or try your hand at some of the finest sportfishing in the world.

Note: Your ship will anchor in Cabo San Lucas and use launches to transport all passengers ashore.

The City of Angels always hovers between dream and reality. Once a near-forgotten colonial outpost, the pueblo metamorphosed into an agrarian paradise before reinventing itself as a movie colony. Perhaps no other city owes so much to the technological innovations of the 20th century, from the automobile to the airplane. Little wonder that LA is oft described as the “dream machine.” In LA, reinvention is a way of life. Yet this talent for change has created a city with a rich ethnic diversity and a sizzling culture. LA is the source for trends that migrate across the country and then the world. Where else can you enjoy a Thai taco or munch on a kosher burrito? Or travel from downtown’s high rises to the beaches of Malibu, shopping in Beverly Hills along the way?

Los Angeles is a port of embarkation and disembarkation for some cruises.